ABSTRACT: Producing microbiological faultless detergents and cosmetics requires an integrated quality management system. This consists of good raw material quality, hygienic design of production facilities, good production hygiene and a validated preservative system. The sustainable use of preservatives is optimised by the antimicrobial stabilization of detergents and cosmetics by utilisation of synergistic effects. Hazard analysis critical control point (HACCP) is a systematic preventive approach to safeguard microbiological faultless quality of products. The requirements of ISO 22716 (Cosmetics – Good Manufacturing Practices (GMP) – Guidelines on Good Manufacturing Practices) are demonstrated for the production of aqueous products. Examples of proper hygienic design and adequate hygiene measures are given, as well as a raw material and finished product assessment according to ISO 29621 (Cosmetics – Microbiology – Guidelines for the risk assessment and identification of microbiologically low-risk products).