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Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Hübner N.-O.a · Siebert J.b · Kramer A.a 
A Institute of Hygiene and Environmental Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, and bSchülke & Mayr GmbH, Norderstedt, Germany Skin Pharmacol Physiol 2010;23:244–258 (DOI:10.1159/000314699)


Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical experience both from case reports and prospective controlled trials. Nowadays, octenidine is an established antiseptic in a large field of applications and represents an alternative to older substances such as chlorhexidine, polyvidone-iodine or triclosan. The review is based on the current literature and unpublished original data as well.